1. Pustaka
: Lachman, The Theory&Practice of Industrial Pharmacy, 3rdedition,1986, hal
515
|
Bentuk Kimia
|
HLB
|
Water
dispersibility
|
|
Etilen glikol distearat
|
 1,5 |
No dispersion
|
|
Sorbitan tristearat
|
2,1
|
|
|
Propilen glikol monostearat
|
3,4
|
|
|
Sorbitan seskuiolea
|
3,7
|
|
|
|
|
|
|
Gliseril monostearat,
non-self-emulsifying
|
 3,8 |
Poor dispersion
|
|
Propilen glikol monolaurat
|
4,5
|
|
|
Sorbitan monostearat
|
4,7
|
|
|
Dietilen glikol monostearat
|
4,7
|
|
|
Gliseril monostearat,
self-emulsifying
|
5,5
|
|
|
|
|
|
|
Dietilen glikol monolaurat
|
6,1 |
Milky dispersion ( not stable )
|
|
Sorbitan monopalmitat
|
6,7
|
|
|
Sukrosa dioleat
|
7,1
|
|
|
Polietilen glikol (200)
monooleat
|
8,0
|
|
|
Sorbitan monolaurat
|
8,6
|
|
|
|
|
|
|
Polioksietilen (4) lauril eter
|
 9,5 |
Milky dispersion
( stable ) |
|
Polioksietilen (4) sorbitan
monostearat
|
9,6
|
|
|
Polioksietilen (6) setil eter
|
10,3
|
|
|
|
|
|
|
Polioksietilen (20) sorbitan
tristearat
|
 10,5 |
Translucent to
clear
dispersion |
|
Polioksietilen glikol (400)
monooleat
|
11,4
|
|
|
Polioksietilen glikol (400)
monostearat
|
11,6
|
|
|
Polioksietilen (9) nonil fenol
|
13,0
|
|
|
|
|
|
|
Polioksietilen glikol (400)
monolaurat
|
 13,1 |
Clear solution
|
|
Polioksietilen (4) sorbitan
monolaurat
|
13,3
|
|
|
Polioksietilen (20) sorbitan
monooleat
|
15,0
|
|
|
Polioksietilen (20) oleil eter
|
15,4
|
|
|
Polioksietilen (20) sorbitan
monopalmitat
|
15,6
|
|
|
Polioksietilen (20) setil eter
|
15,7
|
|
|
Polioksietilen (40) stearat
|
16,9
|
|
|
Sodium oleat
|
18,0
|
|
|
Polioksietilen (100) stearat
|
18,8
|
|
|
Potasium oleat
|
20,0
|
|
|
Sodium lauril sulfat
|
± 40
|
|
|
|
|
|
2.
Pustaka : Alfred Martyn, Physical
Pharmacy, 4th edition, hal. 372
|
Senyawa
|
HLB
|
|
Asam oleat
|
1
|
|
Polioksietilen sorbitol beeawax derivative (G-1706)
|
2,0
|
|
Sorbitan tristearat
|
2,1
|
|
Gliseril monostearat
|
3,8
|
|
Sorbitan monooleat (Span 80)
|
4,3
|
|
Dietilen glikol monostearat
|
4,7
|
|
Gliseril monostearat, self-emulsifying (Tegin)
|
5,5
|
|
Dietilen glikol monolaurat
|
6,1
|
|
Sorbitan monolaurat (Span 20)
|
8,6
|
|
Polietilen lauril eter (Brij 30)
|
9,5
|
|
Gelatin (Pharmagel B)
|
9,8
|
|
Metil selulosa (Methocel 15 cps)
|
10,5
|
|
Polioksietilen lauril eter (G 3705)
|
10,8
|
|
Polioksietilen monostearat (Myrj 45)
|
11,1
|
|
Trietanolamin oleat
|
12,0
|
|
Polioksietilen alkil fenol (Igepal Ca-630)
|
12,8
|
|
Polioksietilen glikol 400 monolaurat
|
13,1
|
|
Polioksietilen sorbitan monooleat (Tween 80)
|
15,0
|
|
Polioksietilen sorbitan monolaurat (Tween 20)
|
16,7
|
|
Polioksietilen lauril eter (Brij 35)
|
16,9
|
|
Sodium oleat
|
18,0
|
|
Potassium oleat
|
20
|
|
Sodium lauril sulfat
|
40
|
|
|
|
3. Nilai HLB untuk Sejumlah Surfaktan
Pustaka : Robert.E.King : “ Dispensing of Medication “ 9th edition
hal 117
|
Generik/Nama kimia
|
Nama Dagang
|
HLB
|
|
Gycerol monostearat
|
Tegin 515
|
3,8
|
|
Sorbitan monooleat
|
Span 80
|
4.3
|
|
Acasia
|
-
|
8,0
|
|
Tragacanth
|
-
|
13,2
|
|
Polyoxyethylene
sorbitan monooleat(Polysorbate 80 USP)
|
Tween 80
|
15,0
|
|
Polyoxyethylene
monostearat (Polyoxyl 40
stearat USP) |
Myrj 52
|
16,9
|
|
Sodium lauril sulfat
|
-
|
40,0
|
NILAI HLB Butuh (RHLB)
1. Nilai HLB Butuh lemak yang biasa digunakan
Pustaka
: Lachman, The Theory&Practice of Industrial Pharmacy, 3rdedition, 1986,
hal 516
|
|
Emulsi m/a
|
Emulsi a/m
|
|
Setil alkohol
|
15
|
-
|
|
Stearil alkohol
|
14
|
-
|
|
Asam stearat
|
15
|
-
|
|
Lanolin, anhidrat
|
10
|
8
|
|
Minyak mineral
|
12
|
-
|
|
Cottonseed oil
|
10
|
5
|
|
Petrolatum
|
12
|
5
|
|
Beeswax
|
12
|
4
|
|
Paraffin wax
|
11
|
4
|
2. Nilai HLB butuh
untuk beberapa minyak
Pustaka
: Alfred Martyn, Physical Pharmacy, 4th edition, hal. 372
|
|
Emulsi m/a
|
Emulsi a/m
|
|
Cottonseed oil
|
7-Jun
|
-
|
|
Petrolatum
|
8
|
-
|
|
Beeswax
|
11-Sep
|
5
|
|
Paraffin wax
|
10
|
4
|
|
Mineral oil
|
12-Oct
|
5 - 6
|
|
Metil silikon
|
11
|
-
|
|
Lanolin, anhidrat
|
14-Dec
|
8
|
|
Carnauba wax
|
14-Dec
|
-
|
|
Lauril alkohol
|
14
|
-
|
|
Castor oil
|
14
|
-
|
|
Kerosene
|
14-Dec
|
-
|
|
Setil alkohol
|
13-16
|
-
|
|
Stearil alkohol
|
15-16
|
-
|
|
Karbon tetraklorida
|
16
|
-
|
|
Asam laurat
|
16
|
-
|
|
Asam oleat
|
17
|
-
|
|
Asam stearat
|
17
|
-
|
3. Nilai HLB butuh
pada bahan-bahan minyak untuk emulsi minyak-air (m/a)
Pustaka : Robert.E.King : “ Dispensing of Medication “ 9th edition,
hal. 116
|
Bahan
|
HLB butuh
|
|
Asam laurat
|
15-16
|
|
Asam oleat
|
17
|
|
Setil alkohol
|
15
|
|
Lauril alkohol
|
14
|
|
Beeswax
|
9
|
|
Carbon tetraklorida
|
16
|
|
Carnauba wax
|
12
|
|
Castor oil
|
14
|
|
Cotton seed oil
|
6
|
|
Kerosene
|
14
|
|
Lanolin anhidrat
|
12
|
|
Methyl silicone
|
11
|
|
Mineral oil
|
11
|
|
Paraffin wax
|
10
|
|
Petrolatum
|
7 – 8
|
Keterangan : HLB tinggi = Hidrofobik
HLB
rendah = Hidrofilik
4. Nilai HLB butuh pada beberapa bahan (fats and oils) berdasarkan
nomenklatur INCI (www.ConvergentCosmetics.com)
|
Aleurites Moluccana Seed Oil
|
7
|
|
Grape (Vitis Vinifera) Seed Oil
|
7
|
|
Almond Oil NF
|
6
|
|
Hybrid Safflower (Carthamus Tinctorius) Oil
|
9
|
|
Anhydrous Lanolin USP
|
10
|
|
Isopropyl Myristate
|
11.5
|
|
Apricot Kernel Oil
|
7
|
|
Isopropyl Palmitate
|
11.5
|
|
Avocado (Persea Gratissima) Oil
|
7
|
|
Jojoba (Buxus Chinensis) Oil
|
6.5
|
|
Babassu Oil
|
8
|
|
Lanolin
|
10
|
|
Beeswax
|
12
|
|
Macadamia (Ternifolia) Nut Oil
|
7
|
|
Borage (Borago Officinalis) Seed Oil
|
7
|
|
Mangifera Indica (Mango) Seed Butter
|
8
|
|
Brazil Nut Oil
|
8
|
|
Mineral Oil
|
10.5
|
|
C12-15 Alkyl Benzoate
|
13
|
|
Myristyl Myristate
|
8.5
|
|
Cannabis Sativa Seed Oil
|
7
|
|
Olive (Olea Europaea) Oil
|
7
|
|
Canola Oil
|
7
|
|
Oryza Sativa (Rice Bran) Oil
|
7
|
|
Caprylic/Capric Triglyceride
|
5
|
|
Peanut Oil NF
|
6
|
|
Carrot (Daucus Carota Sativa) Seed Oil
|
6
|
|
Petrolatum
|
7
|
|
Castor (Ricinus Communis) Oil
|
14
|
|
PPG-15 Stearyl Ether
|
7
|
|
Ceresin
|
8
|
|
Retinyl Palmitate
|
6
|
|
Cetearyl Alcohol
|
15.5
|
|
Safflower (Carthamus Tinctorius) Oil
|
8
|
|
Cetyl Alcohol
|
15.5
|
|
Seed Oil
|
6
|
|
Cetyl Esters
|
10
|
|
Sesame (Sesamum Indicum) Oil
|
7
|
|
Cetyl Palmitate
|
10
|
|
Shea Butter (Butyrospermum Parkii)
|
8
|
|
Coconut Oil
|
8
|
|
Soybean (Glycine Soja) Oil
|
7
|
|
Daucus Carota Sativa (Carrot) Root Extract
|
6
|
|
Stearic Acid
|
15
|
|
Diisopropyl Adipate
|
9
|
|
Stearyl Alcohol
|
15.5
|
|
Dimethicone
|
5
|
|
Sunflower (Helianthus Annus) Oil
|
7
|
|
Dog Rose (Rosa Canina) Hips Oil
|
7
|
|
Sweet Almond (Prunus Amygdalus Dulcis) Oil
|
7
|
|
Emu Oil
|
8
|
|
Theobroma Cacao (Cocoa) Seed Butter
|
6
|
|
Evening Primrose Oil
|
7
|
|
Tocopherol
|
6
|
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